Results
| PMID | 22578534 |
| Gene Name | SOD1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 91 |
| Population details | 91 infertile women (23 infertile women with endometriosis and 68 controls including infertile women due to tubal factor, male factor, or healthy egg donors) |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Female infertility, endometriosis |
|
Fertil Steril. 2012 Jul;98(1):126-30. doi: 10.1016/j.fertnstert.2012.03.052. Epub Prieto, Laura| Quesada, Juan F| Cambero, Olivia| Pacheco, Alberto| Pellicer, Antonio| Codoceo, Rosa| Garcia-Velasco, Juan A Department of Obstetrics and Gynecology, La Paz Hospital, Madrid, Spain. OBJECTIVE: To study the levels of four markers of oxidative stress in follicular fluid (FF) and plasma of patients with infertility related to endometriosis and controls. DESIGN: Experimental study. SETTING: University-affiliated hospital and infertility center. PATIENT(S): Ninety-one infertile women were included in the study (23 infertile women with endometriosis and 68 controls including infertile women due to tubal factor, male factor, or healthy egg donors). INTERVENTION(S): Blood was obtained at the time of egg retrieval, and FF from the mature follicles of each ovary was centrifuged and frozen until analysis. MAIN OUTCOME MEASURE(S): Vitamin C and E, malondialdehyde, and superoxide dismutase concentrations in plasma and follicular fluid. RESULT(S): Women with endometriosis showed a lower vitamin C concentration in FF (12.7 +/- 5.9 vs. 9.7 +/- 6.9 mug/mL) and lower superoxide dismutase concentration in plasma (0.9 +/- 1.4 vs. 0.5 +/- 0.7 U/mL) compared with controls. Vitamin E plasma levels were significantly higher in women with endometriosis (8.1 +/- 3.8 vs. 5.2 +/- 3.2 mug/mL). A nonsignificant trend toward a lower plasma concentration of malondialdehyde was found in women with endometriosis. CONCLUSION(S): These findings suggest a lower antioxidant capacity in infertile women with endometriosis. Although a certain level of reactive oxygen species is required under physiological conditions, an altered balance between pro-oxidant and antioxidant activities may have an impact on folliculogenesis and adequate embryo development. Mesh Terms: Adult| Ascorbic Acid/analysis/blood| Biomarkers/*analysis/blood/metabolism| Case-Control Studies| *Endometriosis/blood/complications/diagnosis/metabolism| Female| Follicular Fluid/*chemistry/metabolism| Humans| *Infertility, Female/blood/diagnosis |
|